Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002p053 | (1) | SRF2015

Investigating the action of 1,25(OH)2D3/vitamin D3 in the human ovary: relevance to fertility and polycystic ovary syndrome (PCOS)

Standing Andrew , Georgiou Christiana , Bano Gul , Mason Helen Diane , Rice Suman

In recent years it has become apparent that vitamin D3 (VD) has a fundamental role in reproductive function, with deficiency of the hormone being implicated in several reproductive pathologies: endometriosis, pre-eclampsia and PCOS. VD is essential for oestrogen synthesis in both males and females; via indirect mechanisms of calcium homeostasis but also direct regulation of aromatase expression. Women with PCOS are more likely to suffer from VD deficiency, with an inverse corr...